Table 3 Body weight, FBG, FTA and insulin level.

Subgroup	Body weight (g)	Insulin (ng/ml)	FBG level (mg/dl)	FTA (µmol/l)
HGI	164.1 ± 2.1	3.1 ± 0.4	95.4 ± 1.3	141.2 ± 1.3
HGII	161.2 ± 1.5	2.9 ± 0.2	101.2 ± 6.4	140.2 ± 4.8
HGIII	165.4 ± 1.9	3.2 ± 0.1	99.4 ± 3.2	145.6 ± 1.1
HGIV	166.2 ± 3.4	3.1 ± 0.8	96.5 ± 2.1	139.4 ± 2.7
HGV	165.7 ± 4.3	2.8 ± 0.5	102.4 ± 1.4	138.4 ± 4.2
HGVI	163.2 ± 1.7	3 ± 0.3	99.1 ± 5.5	146.4 ± 4.3
HGVII	167.4 ± 0.9	3.4 ± 0.7	100.1 ± 2.3	140.1 ± 3.9
DGI	125.4 ± 1.1^#	1.1 ± 1.1^#	299.4 ± 4.4^#	300.1 ± 1.4^#
DGII	135.4 ± 3.1^#	1.2 ± 0.2^#	199.4 ± 1.8^#	245.2 ± 2.6^#
DGIII	145.3 ± 2.7^#	2.1 ± 0.6^#	156.4 ± 6.3^#	194.9 ± 2.1^#
DGIV	136.4 ± 5.9^#	0.9 ± 0.7^#	222.4 ± 3.3^#	278.1 ± 3.7^#
DGV	139.7 ± 4.6^#	0.8 ± 0.3^#	230.1 ± 2.5^#	270.2 ± 1.1^#
DGVI	164.4 ± 2.2*	3.1 ± 1.2*	103.2 ± 1.4*	147.1 ± 1.6*
DGVII	164.2 ± 2.1*	2.9 ± 1.6*	102.1 ± 7.1*	140.1 ± 2.2*

Data were presented as mean ± SEM, *represented a significance difference in comparison to diabetic untreated subgroup DGI and ^#represented a significance difference in comparison to healthy control subgroup HGI at p < 0.05 by One Way ANOVA and Tukey post hoc test (n = 6). HGI Control untreated rats, HGII Healthy rats that received free Mel (5 mg/kg), HGIII Healthy rats that received free Mel (10 mg/kg), HGIV Healthy rats that received unloaded C/L nanoparticles (5 mg/kg), HGV Healthy rats that received unloaded C/L nanoparticles (10 mg/kg), HGVI Healthy rats that received Mel-C/L nanoparticles (5 mg/kg), HGVII Healthy rats that received Mel-C/L nanoparticles (10 mg/kg), DGI Control untreated rats, DGII Diabetic rats that received free Mel (5 mg/kg), DGIII Diabetic rats that received free Mel (10 mg/kg), DGIV Diabetic rats that received unloaded C/L nanoparticles (5 mg/kg), DGV Diabetic rats that received unloaded C/L nanoparticles (10 mg/kg), DGVI Diabetic rats that received Mel-C/L nanoparticles (5 mg/kg), DGVII Diabetic rats that received Mel-C/L nanoparticles (10 mg/kg).

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