Figure 7 | Scientific Reports

Figure 7

From: Divalent cations in human liver pyruvate kinase exemplify the combined effects of complex-equilibrium and allosteric regulation

Figure 7

The influence of varying concentrations of Co2+ on allosteric inhibition of PEP affinity by alanine and the allosteric activation of PEP affinity by Fru-1,6-BP. The response to varying concentrations of Co2+ in the lower panel includes the same data from Fig. 3. Lines in the first two rows of panels represent data fits to Eq. (1). The activity response at the highest concentration of Ala (pink data) are not fit in all graphs (top row). Error bars in the third row of panels represent error estimates from the parameter fits of the data in the first two rows of panels. When error bars are not visible, they are smaller than data points. Lines in the third row of panels represent data fits to Eq. (2).

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