Table 4 Interaction between retinol intake and ISX rs5755368 polymorphism (dominant model) in colorectal cancer risk.

From: Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population

ISX rs5755368

AG/GG

AA

P interaction

Total (n = 1419)

T1 (< 48.75)

T2 (48.75–88.17)

T3 (> 88.17)

T1 (< 48.75)

T2 (48.75–88.17)

T3 (> 88.17)

No. of controls/cases

97/114

94/75

89/53

167/176

193/127

179/55

 

Model 1 [OR (95% CI)]

1.00

0.68 (0.45–1.02)

0.51 (0.33–0.78)

0.90 (0.64–1.27)

0.56 (0.39–0.80)

0.26 (0.17–0.39)

0.076

Model 2 [OR (95% CI)]

1.00

0.77 (0.47–1.26)

0.76 (0.45–1.30)

0.97 (0.64–1.48)

0.66 (0.43–1.01)

0.32 (0.20–0.53)

0.026

Men (n = 944)

T1 (< 47.20)

T2 (47.20–83.41)

T3 (> 83.41)

T1 (< 47.20)

T2 (47.20–83.41)

T3 (> 83.41)

 

No. of controls/cases

67/85

61/40

60/43

110/116

121/84

119/38

 

Model 1 [OR (95% CI)]

1.00

0.52 (0.31–0.86)

0.57 (0.34–0.94)

0.83 (0.55–1.26)

0.55 (0.36–0.84)

0.25 (0.16–0.41)

0.116

Model 2 [OR (95% CI)]

1.00

0.54 (0.28–1.05)

0.69 (0.37–1.30)

0.94 (0.55–1.59)

0.67 (0.39–1.15)

0.28 (0.15–0.52)

0.086

Women (n = 475)

T1 (< 51.54)

T2 (51.54–98.79)

T3 (> 98.79)

T1 (< 51.54)

T2 (51.54–98.79)

T3 (> 98.79)

 

No. of controls/cases

32/28

28/30

32/16

56/58

76/41

57/21

 

Model 1 [OR (95% CI)]

1.00

1.22 (0.59–2.52)

0.57 (0.26–1.25)

1.18 (0.63–2.21)

0.62 (0.33–1.16)

0.42 (0.21–0.86)

0.264

Model 2 [OR (95% CI)]

1.00

1.43 (0.60–3.44)

1.47 (0.55–3.93)

1.02 (0.47–2.23)

0.79 (0.36–1.75)

0.69 (0.29–1.67)

0.196

  1. Model 1: crude model. Model 2: multivariate model, adjusted for age, sex, body mass index (BMI), family history of colorectal cancer, smoking status, alcohol consumption, regular exercise, education, occupation, monthly income, married status, and total energy intake.
  2. T tertile (µg/day).
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