Figure 2
From: Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice
ERβ partially mediates 17α-E2 effects on calorie consumption in obese female, but not male, mice. (A) Average weekly calorie consumption during baseline (week 0) and throughout the first 4 weeks of treatment in male WT and ERβKO mice [n = 9–10/group/timepoint]. (B) Average weekly calorie consumption during baseline (week 0) and throughout the first 4 weeks of treatment in female WT and ERβKO mice [n = 7–9/group/timepoint]. Age-matched, WT, LFD-fed mice were also evaluated as a normal-weight reference group and their corresponding means for both sexes are depicted as dashed yellow lines [n = 9/group/timepoint]. All data are presented as mean ± SEM and were analyzed within sex by two-way repeated measures ANOVA with Tukey post-hoc comparisons. * represents differences within genotypes across treatment groups at each timepoint. *p < 0.05.
