Figure 4
Lung compression led to downregulation of three genes within E21.5 mvECs that defined a subpopulation of endothelial cells relevant to alveolar formation and response to injury. CDH mvEC were compared to NC mvEC to detect differences that were most clearly related to lung compression instead of nitrofen-exposure. This comparison revealed reductions in carbonic anhdyrase IV (Ca4), apelin (Apln) and endothelin receptor type B (Ednrb) genes in CDH, which characterize a previously identified subpopulation of enodthelial cells that participate in gas exchange, alveolar formation and repair of lung injury. Asterixes identify statistically significant changes with the number of asterixes identifying how many significant zeros there are in the p-value. The number above or below the asterixes is the log2 fold change in the CDH cells.
