Figure 3 | Scientific Reports

Figure 3

From: Shotgun proteomics identification of proteins expressed in the Descemet’s membrane of patients with Fuchs endothelial corneal dystrophy

Figure 3

Gene ontology and reactome analyses of 32 proteins identified only in Descemet’s membrane (DM) of patients with FECD (Fuchs endothelial corneal dystrophy). (A) The 32 proteins identified only in the DM of the patient with FECD but not in the DM of non-FECD subject were subjected to the Gene Ontology (GO) analysis. The top 8 significantly enriched GO terms of the biological process, cellular component, and molecular function are shown. Multiple extracellular matrix-related GO terms were enriched. The significance of each GO term was represented by -log10 (P-value) with a color bar ranging from blue to red. (B) The 32 proteins identified only in the DM of the patient with FECD were subjected to the Reactome analysis. Multiple extracellular matrix-related pathways involving ECM organization, integrin cell surface interaction, and ECM proteoglycans were significantly enriched. The color bar indicates the significance of each pathway represented by − log10 (P-value) ranging from blue to red.

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