Table 2 Top 30 proteins identified in the Descemet’s membrane of a control subject without Fuchs endothelial corneal dystrophy.
Protein name | Gene symbol | Ensembl gene ID | UniProtKB ID | Mascot score |
|---|---|---|---|---|
Myosin-9 | MYH9 | ENSG00000100345 | P35579 | 2709.9 |
Plectin | PLEC | ENSG00000178209 | Q15149 | 2487.9 |
Myosin-10 | MYH10 | ENSG00000133026 | P35580 | 2312.7 |
Vimentin | VIM | ENSG00000026025 | P08670 | 1621.2 |
Neuroblast Differentiation-Associated Protein AHNAK | AHNAK | ENSG00000124942 | Q09666 | 1465.6 |
Endoplasmic reticulum chaperone BiP | HSPA5 | ENSG00000044574 | P11021 | 1200.7 |
Collagen alpha-1(XII) chain | COL12A1 | ENSG00000111799 | Q99715 | 1197.3 |
Alpha-enolase | ENO1 | ENSG00000074800 | P06733 | 1158.9 |
Transforming growth factor-beta-induced protein ig-h3 | TGFBI | ENSG00000120708 | Q15582 | 1066.3 |
Endoplasmin | HSP90B1 | ENSG00000166598 | P14625 | 980.3 |
Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | ENSG00000142798 | P98160 | 957.3 |
Protein disulfide-isomerase A3 | PDIA3 | ENSG00000167004 | P30101 | 914.8 |
ATP synthase subunit beta, mitochondrial | ATP5B | ENSG00000110955 | P06576 | 886.5 |
Laminin subunit alpha-5 | LAMA5 | ENSG00000130702 | O15230 | 877.7 |
Myocilin | MYOC | ENSG00000034971 | Q99972 | 876.9 |
Pyruvate kinase PKM | PKM | ENSG00000067225 | P14618 | 856.7 |
60 kDa heat shock protein, mitochondrial | HSPD1 | ENSG00000144381 | P10809 | 810.6 |
ATP synthase subunit alpha, mitochondrial | ATP5A1 | ENSG00000152234 | P25705 | 797.8 |
Actin, cytoplasmic 1 | ACTB | ENSG00000075624 | P60709 | 785.6 |
Ribosome-binding protein 1 | RRBP1 | ENSG00000125844 | Q9P2E9 | 776.2 |
Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | ENSG00000111640 | P04406 | 775.3 |
Prelamin-A/C | LMNA | ENSG00000160789 | P02545 | 743.4 |
Heat shock protein HSP 90-beta | HSP90AB1 | ENSG00000096384 | P08238 | 723.6 |
Annexin A2 | ANXA2 | ENSG00000182718 | P07355 | 711.7 |
Stress-70 protein, mitochondrial | HSPA9 | ENSG00000113013 | P38646 | 709.5 |
Cytoskeleton-associated protein 4 | CKAP4 | ENSG00000136026 | Q07065 | 668.1 |
Heat shock cognate 71 kDa protein | HSPA8 | ENSG00000109971 | P11142 | 645.5 |
Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 | ENSG00000163399 | P05023 | 620.0 |
Fructose-bisphosphate aldolase A | ALDOA | ENSG00000149925 | P04075 | 596.2 |
