Table 3 Top 30 proteins identified in the Descemet’s membrane of a patient with Fuchs endothelial corneal dystrophy.
Protein name | Gene symbol | Ensembl gene ID | UniProtKB ID | Mascot score |
|---|---|---|---|---|
Collagen alpha-1(XII) chain | COL12A1 | ENSG00000111799 | Q99715 | 2781.1 |
Transforming growth factor-beta-induced protein ig-h3 | TGFBI | ENSG00000120708 | Q15582 | 1003.6 |
Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | ENSG00000142798 | P98160 | 633.9 |
Vimentin | VIM | ENSG00000026025 | P08670 | 613.5 |
Collagen alpha-3(VI) chain | COL6A3 | ENSG00000163359 | P12111 | 602.5 |
Thrombospondin-1 | THBS1 | ENSG00000137801 | P07996 | 577.8 |
Myosin-10 | MYH10 | ENSG00000133026 | P35580 | 510.7 |
Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 | ENSG00000163399 | P05023 | 483.3 |
Laminin subunit alpha-5 | LAMA5 | ENSG00000130702 | O15230 | 452.0 |
ATP synthase subunit alpha, mitochondrial | ATP5A1 | ENSG00000152234 | P25705 | 399.1 |
Myosin-9 | MYH9 | ENSG00000100345 | P35579 | 355.3 |
Annexin A2 | ANXA2 | ENSG00000182718 | P07355 | 327.1 |
Actin, cytoplasmic 1 | ACTB | ENSG00000075624 | P60709 | 326.4 |
EMILIN-1 | EMILIN1 | ENSG00000138080 | Q9Y6C2 | 316.2 |
Clusterin | CLU | ENSG00000120885 | P10909 | 310.2 |
Laminin subunit gamma-1 | LAMC1 | ENSG00000135862 | P11047 | 308.4 |
Plectin | PLEC | ENSG00000178209 | Q15149 | 308.3 |
Fibronectin | FN1 | ENSG00000115414 | P02751 | 303.8 |
Alpha-enolase | ENO1 | ENSG00000074800 | P06733 | 268.5 |
Histone H4 | HIST1H4I | ENSG00000276180 | P62805 | 239.7 |
Fibrinogen alpha chain | FGA | ENSG00000171560 | P02671 | 238.9 |
Cytoskeleton-associated protein 4 | CKAP4 | ENSG00000136026 | Q07065 | 237.8 |
ATP synthase subunit beta, mitochondrial | ATP5B | ENSG00000110955 | P06576 | 218.3 |
Hemoglobin subunit alpha | hba1 | ENSG00000206172 | P69905 | 208.3 |
Hemoglobin subunit beta | HBB | ENSG00000244734 | P68871 | 205.7 |
Filamin-A | FLNA | ENSG00000196924 | P21333 | 197.5 |
Annexin A1 | ANXA1 | ENSG00000135046 | P04083 | 193.1 |
Endoplasmin | HSP90B1 | ENSG00000166598 | P14625 | 190.4 |
Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | ENSG00000111640 | P04406 | 159.2 |
