Table 1 Amino acid differences between the 2019–2020 viruses chosen for characterization compared with the 2018–2019 A5a virus (A/Baltimore/R0496/2018).

From: 2019–2020 H1N1 clade A5a.1 viruses have better in vitro fitness compared with the co-circulating A5a.2 clade

 

A/Baltimore/R0675/2019 (A5a.2)

A/Baltimore/R0686/2019 (A5a.1)

A/Baltimore/R0688/2019 (A5a.1)

HA1

K130N/N156K/L161I/V250A

R45K/T120I/D187A/Q189E

D187A/Q189E

HA2

E179D

  

NA

M19T/Y66F/N222K

S52N/I223V

I40T/S52N/T72N

M1

   

M2

H81Q

E70D/H81Q

E70D/H81Q

NP

 

A70S/V444I

A70S/V444I

NS1

D189G

D189G

I145V/D189G

NS2

I32V

I32V

I32V

PA

V63L/S225C/I505V

M336R/M374I

K213R/I465M/T528I

PA-X

V63L

 

S213G

PB1

M174V/I728V

I728V

M646L/I728V

PB1-F2

   

PB2

Q183L/R630K

Q183L

Q183L

  1. NP segment numbering was based on the established start codon for H3N2 and H1N1, instead of the recently emerged upstream start codon31.
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