Table 1 The urease inhibitory activities of 6a–o in the enzymatic assessments.

From: [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies

Compound

R

IC50 (µM) ± SD

6a

H

0.87 ± 0.09

6b

2-F

1.51 ± 0.21

6c

3-F

1.40 ± 0.29

6d

4-F

1.01 ± 0.13

6e

2-Cl

8.32 ± 1.21

6f

3-Cl

1.25 ± 0.19

6g

4-Cl

1.68 ± 0.73

6h

3,4-diCl

1.41 ± 0.32

6i

2-Br

1.59 ± 0.14

6j

3-Br

1.05 ± 0.34

6k

4-Br

1.53 ± 0.17

6l

4-NO2

2.22 ± 0.18

6m

2-CH3

1.60 ± 0.23

6n

3-CH3

1.23 ± 0.56

Thioureaa

 

22.54 ± 2.34

  1. Data presented here are the mean ± SD of three independent experiments.
  2. aPositive control.
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