Figure 5
Low concentrations p24 requiring ultrasensitive detection approaches reveal a more diverse repertoire of reactivated HIV-1. Each circle or diamond represents a single, unique RNA genome found through P6-PR-RT single-genome sequencing80 performed on QVOA culture supernatants from RAVEN participant 2147-R. Black triangles represent proviral sequences found in mixed PBMC from RAVEN participant 2147-R. Asterisk denotes stop codons. Sequences were processed to visualize 1–2 nucleotide changes.
