Figure 1
From: Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
Pharmacokinetic profiles of enantiomers L- and D-S-CPP, according to a bicompartment model after a single intravenous injection in rats. Ten-month-old wild-type female Wistar rats were injected in the caudal vein at T0 and blood was collected at different time points until 24 h. Linear graphical representation of plasma concentrations of 3H-L-S-CPP (dose = 6.3 × 107 dpm kg−1, or 32.0 µg kg−1) (A) and 3H-D-S-CPP (dose = 16.2 × 107 dpm kg−1, or 3.5 µg kg−1) (B). Plasma concentrations are presented as the % of the respective calculated initial concentration (C0). Both sets of curves followed a bicompartment PK model with two phases: a rapid distribution phase (illustrated in green with intercept A as distribution coefficient) and a much longer elimination phase (illustrated in orange with intercept B as elimination coefficient) (C). Data are presented as the mean ± SEM. AUC Area under the curve, C0 initial estimated concentration, Cl clearance, D0 initial dose, dpm disintegration per minute, S-CPP Shuttle cell-penetrating peptides, T1/2α/β half-life of distribution (α) and elimination (β), Vd estimated area of the compound’s distribution.
