Figure 2
From: Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
Pharmacokinetic profile of 3H-IgG combined to L-S-CPP, according to a linear model after a single intravenous injection in rats. Ten-month-old wild-type female Wistar rats were injected in the caudal vein at T0 and blood was collected at different time points until 48 h. Linear graphical representation of plasma concentrations of 3H-IgG (at 1.3 × 107 dpm kg−1 = 19.9 µg.kg- 1, or with L-S-CPP (1.4 mg kg−1). Plasma concentrations are represented as the % of the respective calculated initial concentration (C0). Both sets of curves followed a linear PK model. PK parameters are shown in the inserted Tables. Data are presented as mean ± SEM. Statistical analysis: Student’s t-test between 3H-IgG alone compared to the combination with L-S-CPP at equivalent doses for calculated PK parameters. AUC Area under the curve, C0 initial estimated concentration, Cl clearance, Di initial theorical dose, dpm disintegration per minute, Doseextrapolated graphically estimated dose, S-CPP Shuttle cell-penetrating peptides, IgG immunoglobulin G, T1/2 half-life, VD estimated area of the compound’s distribution.
