Table 2 Blood hematology parameters after chronic high dose of S-CPP.
From: Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
PBS (n = 5) | L-S-CPP (n = 7) | D-S-CPP (n = 8) | |||
|---|---|---|---|---|---|
Hematology | Units | Mean ± SEM | Mean ± SEM | Mean ± SEM | |
White Blood Cells | WBC | 103/mm3 | 7.1 ± 2.2 | 6.5 ± 0.9 | 4.4 ± 0.4 |
Lymphocytes | LYM | 103/mm3 | 3.0 ± 1.1 | 3.1 ± 0.4 | 1.9 ± 0.1 |
Monocytes | MON | 103/mm3 | 0.4 ± 0.4 | 0.3 ± 0.2 | 0.1 ± 0.1 |
Granulocytes | GRA | 103/mm3 | 3.6 ± 1.1 | 2.9 ± 0.4 | 2.2 ± 0.2 |
Eosinophils | EOS | 103/mm3 | 0.8 ± 0.5 | 0.5 ± 0.2 | 0.1 ± 0.0 |
% Lymphocytes | LYM | % | 43.9 ± 3.7 | 48.7 ± 1.5 | 43.8 ± 2.6 |
% Monocytes | MON | % | 7.4 ± 1.2 | 9.2 ± 0.9 | 9.7 ± 0.7 |
% Granulocytes | GRA | % | 48.7 ± 3.0 | 42.1 ± 1.8 | 46.5 ± 2.3 |
% Eosinophils | EOS | % | 7.7 ± 3.7 | 5.7 ± 2.0 | 2.2 ± 0.3 |
Red Blood Cells | RBC | 106/mm3 | 8.8 ± 0.3 | 7.8 ± 0.3 | 7.3 ± 0.5 |
Hemoglobin | HGB | g/dl | 13.8 ± 0.5 | 14.0 ± 0.5 | 12.9 ± 0.8 |
% Hematocrit | HCT | % | 40.6 ± 1.4 | 38.3 ± 1.1 | 35.5 ± 2.6 |
Mean Corpuscular Volume | MCV | µm3 | 46.0 ± 0.5 | 49.4 ± 0.6 | 49.0 ± 0.6 |
Mean Cell Hemoglobin | MCH | pg | 15.6 ± 0.2 | 17.9 ± 0.4 | 17.9 ± 0.5 |
Mean Cell Hemoglobin Concentration | MCHC | g/dl | 33.9 ± 0.1 | 36.5 ± 0.8 | 36.6 ± 0.8 |
Red Cell Distribution Width | RDW | % | 14.8 ± 0.3 | 13.9 ± 0.1 | 14.1 ± 0.2 |
Platelets | PLT | 103/mm3 | 884.2 ± 132.5 | 775.1 ± 77.7 | 843.3 ± 108.3 |
Mean Platelet Volume | MPV | µm3 | 5.3 ± 0.1 | 5.7 ± 0.1 | 5.7 ± 0.1 |
