Table 2 Linear regression analysis for relationships between blood inflammatory markers level and BMD and bone strength in femoral neck.

From: Associations between blood inflammatory markers and bone mineral density and strength in the femoral neck: findings from the MIDUS II study

Variables

Model 1

Model 2

Model 3

Per SD change (95% CI)

P value

Per SD change (95% CI)

P value

Per SD change (95% CI)

P value

Femoral neck BMD (g/cm2)

 IL6 (pg/mL)

0.04 (−0.03, 0.11)

0.233

0.04 (−0.03, 0.10)

0.272

0.00 (−0.06, 0.07)

0.893

 IL8 (pg/mL)

−0.02 (−0.08, 0.05)

0.659

−0.02 (−0.09, 0.05)

0.563

−0.00 (−0.06, 0.06)

0.950

 IL10 (pg/mL)

−0.01 (−0.08, 0.05)

0.705

−0.01 (−0.08, 0.06)

0.733

−0.01 (−0.07, 0.06)

0.854

 TNF-α (pg/mL)

0.08 (0.01, 0.15)

0.025

0.08 (0.01, 0.15)

0.024

0.04 (−0.03, 0.10)

0.260

 Soluble IL6 receptor (pg/mL)

−0.15 (−0.22, −0.08)

 < 0.001

−0.14 (−0.21, −0.08)

 < 0.001

−0.15 (−0.21, −0.09)

 < 0.001

 CRP (μg/mL)

0.17 (0.11, 0.24)

 < 0.001

0.17 (0.11, 0.24)

 < 0.001

0.05 (−0.02, 0.12)

0.137

CSI (g/kg m)

 IL6 (pg/mL)

−0.05 (−0.12, 0.02)

0.166

−0.05 (−0.13, 0.02)

0.129

−0.01 (−0.08, 0.05)

0.654

 IL8 (pg/mL)

0.03 (−0.04, 0.10)

0.459

0.02 (−0.05, 0.09)

0.558

−0.00 (−0.06, 0.06)

0.969

 IL10 (pg/mL)

−0.01 (−0.08, 0.06)

0.776

−0.01 (−0.08, 0.06)

0.815

−0.02 (−0.08, 0.05)

0.638

 TNF-α (pg/mL)

−0.04 (−0.12, 0.03)

0.232

−0.04 (−0.12, 0.03)

0.232

0.01 (−0.06, 0.07)

0.810

 Soluble IL6 receptor (pg/mL)

−0.08 (−0.15, −0.01)

0.029

−0.07 (−0.14, 0.00)

0.050

−0.07 (−0.13, 0.00)

0.039

 CRP (μg/mL)

−0.13 (−0.21, −0.06)

 < 0.001

−0.13 (−0.21, −0.06)

 < 0.001

0.02 (−0.05, 0.09)

0.570

BSI (g/kg m)

 IL6 (pg/mL)

−0.04 (−0.11, 0.03)

0.295

−0.04 (−0.11, 0.03)

0.286

0.01 (−0.06, 0.07)

0.869

 IL8 (pg/mL)

0.01 (−0.06, 0.08)

0.730

0.01 (−0.06, 0.08)

0.797

−0.01 (−0.08, 0.05)

0.633

 IL10 (pg/mL)

−0.01 (−0.08, 0.06)

0.859

−0.01 (−0.08, 0.06)

0.848

−0.01 (−0.08, 0.05)

0.653

 TNF-α (pg/mL)

−0.04 (−0.11, 0.03)

0.260

−0.04 (−0.11, 0.03)

0.263

0.01 (−0.05, 0.08)

0.640

 Soluble IL6 receptor (pg/mL)

−0.07 (−0.14, −0.01)

0.035

−0.07 (−0.14, −0.00)

0.040

−0.07 (−0.13, −0.01)

0.026

 CRP (μg/mL)

−0.14 (−0.21, −0.07)

 < 0.001

−0.14 (−0.21, −0.07)

 < 0.001

0.03 (−0.04, 0.09)

0.376

ISI (g/kg m)

 IL6 (pg/mL)

−0.07 (−0.14, −0.00)

0.045

−0.07 (−0.14, −0.00)

0.038

−0.02 (−0.08, 0.03)

0.410

 IL8 (pg/mL)

0.04 (−0.03, 0.11)

0.296

0.03 (−0.04, 0.10)

0.367

0.00 (−0.05, 0.06)

0.866

 IL10 (pg/mL)

−0.01 (−0.08, 0.06)

0.722

−0.01 (−0.08, 0.06)

0.727

−0.02 (−0.08, 0.04)

0.477

 TNF-α (pg/mL)

−0.04 (−0.11, 0.03)

0.286

−0.04 (−0.11, 0.03)

0.289

0.03 (−0.03, 0.08)

0.397

 Soluble IL6 receptor (pg/mL)

−0.13 (−0.20, −0.06)

 < 0.001

−0.13 (−0.20, −0.06)

 < 0.001

−0.12 (−0.18, −0.06)

 < 0.001

 CRP (μg/mL)

−0.16 (−0.23, −0.09)

 < 0.001

−0.16 (−0.23, −0.09)

 < 0.001

0.03 (−0.03, 0.10)

0.272

  1. Model 1: adjusted for age and gender.
  2. Model 2: adjusted for age, gender, ever smoked cigarettes regularly and number of years drank that much.
  3. Model 3: adjusted for age, gender, ever smoked cigarettes regularly, number of years drank that much, BMI and regular exercise.
  4. BMD bone mineral density, CSI compression strength index, BSI bending strength index, ISI impact strength index, IL interleukin, TNF tumor necrosis factor, CRP C-reactive protein, BMI body mass index.
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