Table 3 Subgroup analysis based medical history for relationships between blood soluble IL6 receptor levels and BMD and bone strength in femoral neck.

From: Associations between blood inflammatory markers and bone mineral density and strength in the femoral neck: findings from the MIDUS II study

Variables

Per SD change (95% CI)

P value

Interaction P

Femoral neck BMD (g/cm2)

 Ever had arthritis

−0.12 (−0.21, −0.03)

0.008

0.348

 NO

−0.18 (−0.26, −0.09)

 < 0.001

 Ever had stroke

−0.08 (−0.46, 0.30)

0.696

0.726

 NO

−0.15 (−0.22, −0.09)

 < 0.001

 Ever had diabetes

−0.18 (−0.37, 0.00)

0.058

0.525

 NO

−0.14 (−0.20, −0.07)

 < 0.001

 Ever had cancer

−0.04 (−0.22, 0.15)

0.699

0.199

 NO

−0.16 (−0.23, −0.09)

 < 0.001

CSI (g/kg m)

 Ever had arthritis

0.01 (−0.08, 0.09)

0.911

0.030

 NO

−0.13 (−0.22, −0.05)

0.003

 Ever had stroke

−0.18 (−0.63, 0.28)

0.454

0.638

 NO

−0.07 (−0.13, −0.01)

0.035

 Ever had diabetes

−0.14 (−0.32, 0.03)

0.108

0.409

 NO

−0.06 (−0.13, 0.01)

0.098

 Ever had cancer

−0.03 (−0.19, 0.13)

0.735

0.654

 NO

−0.07 (−0.14, −0.00)

0.042

BSI (g/kg m)

 Ever had arthritis

−0.03 (−0.13, 0.06)

0.479

0.236

 NO

−0.11 (−0.19, −0.03)

0.008

 Ever had stroke

−0.34 (−1.12, 0.43)

0.394

0.206

 NO

−0.07 (−0.13, −0.01)

0.019

 Ever had diabetes

−0.11 (−0.27, 0.05)

0.184

0.728

 NO

−0.07 (−0.14, −0.00)

0.037

 Ever had cancer

−0.01 (−0.22, 0.20)

0.913

0.458

 NO

−0.08 (−0.15, −0.02)

0.011

ISI (g/kg m)

 Ever had arthritis

−0.07 (−0.16, 0.02)

0.117

0.050

 NO

−0.17 (−0.25, −0.10)

 < 0.001

 Ever had stroke

−0.15 (−0.72, 0.42)

0.615

0.915

 NO

−0.13 (−0.18, −0.07)

 < 0.001

 Ever had diabetes

−0.15 (−0.31, 0.02)

0.087

0.828

 NO

−0.12 (−0.19, −0.06)

 < 0.001

 Ever had cancer

−0.03 (−0.22, 0.16)

0.790

0.212

 NO

−0.14 (−0.20, −0.08)

 
  1. Adjusted for age, gender, ever smoked cigarettes regularly, number of years drank that much, BMI and regular exercise.
  2. BMD bone mineral density, CSI compression strength index, BSI bending strength index, ISI impact strength index, IL interleukin.