Table 3 Mean ± SD blood flow (BF) values of carcinoma (ROI4) and parenchyma (ROI5) tissue for polygonal ROI using FPA1, FPA2 at all ten acquisition times and MSM.

From: Evaluation and timing optimization of CT perfusion first pass analysis in comparison to maximum slope model in pancreatic adenocarcinoma

Tissue type

FPA1

FPA2

MSM

tmax

t1

t2

t3

t4

t5

t6

t7

t8

t9

t10

Polygonal ROI blood flow (ml/100 ml/min) measurement

 Carcinoma

42.3 ± 16.4

49.5 ± 18.0

44.2 ± 15.7

46.9 ± 18.3

44.2 ± 18.7

39.6 ± 14.7

42.5 ± 16.3

41.9 ± 16.9

44.7 ± 17.8

51.4 ± 19.4

54.1 ± 22.5

53.7 ± 23.9

 Parenchyma

74.6 ± 29.6

82.6 ± 34.7

84.9 ± 34.8

80.5 ± 32.3

78.5 ± 31.4

76.0 ± 32.7

73.7 ± 30.8

76.1 ± 28.8

80.5 ± 32.5

87.8 ± 34.9

97.9 ± 38.9

91.2 ± 37.1

 T-test (p value)

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 Pearson’s correlation (r)

0.66

0.38

0.55

0.57

0.56

0.66

0.72*

0.75*

0.73*

0.72*

0.67

 
  1. Polygonal ROIs were used to circumscribe respective tissues for voxel-by-voxel analysis. Student’s t-test p value for voxel values in polygonal ROIs shows a significant difference between carcinoma and parenchyma at all ten acquisition times. Correlation values marked with an asterisk show the range of acquisition time (t6–t9) with the highest correlation (r > 0.7) between FPA2 and MSM for each voxel value in the polygonal ROI.
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