Figure 2

Sex differences in cardiac remodeling across degrees of AR severity. The association between the regurgitant volume (RVol) and absolute/ indexed ventricular volumes, mass and LVEF variables were depicted by the quadratic prediction plots with confidence interval bands and stratified by gender. The coefficients representing the difference in the evaluated variables between genders were obtained from the multivariable generalized linear modeling (GLM) in all patients. The P-values representing the difference in the evaluated variables between genders were obtained from the similar GLM models in patients having aortic RVol > 30 mL. The GLM models were adjusted for gender, diabetes, RVol, aortic valve morphology, and interaction term of aortic Rvol and sex. LVEDV left ventricular end diastolic volume, LVESV left ventricular end systolic volume, LVEF left ventricular ejection fraction.