Figure 4
From: A short pre-conception bout of predation risk affects both children and grandchildren
Pre-conception predator stress increases c-FOS expression after a mild stressor in F1 mice. (A) Schematic of F1 cFOS procedure. (B) Representative cFOS images in the dorsal hippocampus in offspring from either preconception predator-stressed parents (PS F1) or control parents (control F1). Expression of cFOS was measured in the hippocampus within the dorsal dentate gyrus, left and right hemisphere (DENTRH, DENTLH), ventral dentate gyrus, left and right hemisphere (VDLH, VDRH), dorsal CA1, left and right hemisphere (CA1LH, CA1RH), and ventral CA1, left and right hemisphere (VCA1LH, VCA1RH). (C) Mean ± SEM of cFOS in different brain regions. Following the mild stressor, offspring from predator stressed parents show elevated cFOS in the dentate and CA1 (ventral and dorsal, both hemispheres) compared to offspring from control parents. C control, PS predator stress. ***p < 0.001.
