Figure 4
From: Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
Helical conformation of p27 KID bound to CDK2-cyclin A. The CDK2, cyclin A and p27 subunits of the hexameric complex are shown in blue, purple and yellow respectively. The CDK2-cyclin A modules of CDK2-cyclin A-p27 (PDB 1JSU (grey)) and the octameric SCFSKP2 E3 ligase structure (PDB 7B5R (salmon)) were superposed with the hexameric CDK2-cyclin A module, and the p27 domains rendered in grey (PDB 1JSU), salmon (PDB 7B5R) and yellow (hexameric complex) respectively, to reveal different helical conformations for p27 KID when bound to CDK2-cyclin A.
