Table 4 Paw volume measurement after treatment with methyl gallate and its synthetic derivative.

From: Lipoxygenase inhibitory synthetic derivatives of methyl gallate regulate gene expressions of COX-2 and cytokines to reduce animal model arthritis

Group

Paw volume (mL) (mean ± SEM)

Percentage of inhibition

Initial day

9th day

18th day

28th day

Healthy rat

0.50 ± 0.05

0.53 ± 0.16#

0.55 ± 0.22#

0.53 ± 0.08#

 

Arthritic control

0.53 ± 0.05

1.84 ± 0.16

2.49 ± 0.05

3.04 ± 0.05

 

Diclofenac (10 mg.kg−1)

0.56 ± 0.05

1.44 ± 0.16

0.8 ± 0.22#

0.73 ± 0.08#

59%

Methyl gallate (20 mg.kg−1)

0.56 ± 0.05

1.32 ± 0.16*

1.24 ± 0.22#

1.18 ± 0.08#

45%

Methyl gallate (40 mg.kg−1)

0.50 ± 0.05

1.66 ± 0.18*

1.56 ± 0.24*

1.4 ± 0.09#

37%

MGSD 1 (1 mg.kg−1)

0.50 ± 05

0.97 ± 0.16

0.68 ± 0.22*

0.59 ± 0.08#

68%

MGSD 1 (10 mg.kg−1)

0.50 ± 0.05

1.05 ± 0.16

0.69 ± 0.22#

0.56 ± 0.08#

70%

  1. Values are expressed as mean ± SEM (n = 6). Symbols represent statistical significance #,*. #p < 0.01 and *p < 0.05 as compared to arthritic control.
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