Figure 1 | Scientific Reports

Figure 1

From: Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway

Figure 1

Short- and long-term effects of adolescent repeated ALP exposure on body weight. Body weights of C57BL/6 J male adolescent mice throughout repeated alprazolam exposure. (A) Mice were habituated for one week (PD28-34) then exposed to 14 days to either vehicle (VEH) or alprazolam (ALP; n = 12/group). The mice were exposed to the conditioned place preference (CPP) paradigm with morphine (MOR) either 24 h (Short-term) or 1 month (Long-term) after the last ALP injection. (B) Mice in the short-term condition gained weight over time (p < 0.0001) regardless of treatment condition. (C) Likewise, mice in the long-term condition gained weight over time (p < 0.0001), with the ALP 0.5 mg/kg weighting more than the ALP 1.0 mg/kg group (p < 0.05). Shaded region indicates days of ALP exposure. *p < 0.05 when compared to ALP (1.0 mg/kg) pretreated mice. εp < 0.05 when compared to VEH-pretreated mice. All data are expressed as the mean ± SEM.

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