Figure 2 | Scientific Reports

Figure 2

From: Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway

Figure 2

Short- and long-term effects of adolescent repeated ALP exposure on morphine place conditioning. Effects of repeated exposure to vehicle (VEH) or alprazolam (ALP) during adolescence on morphine-induced conditioned place preference. (A) Mice were habituated for one week (PD28-34) then exposed to 14 days to either vehicle (VEH) or alprazolam (ALP; n = 7–8/group). (B) Short-term (24 h after the last injection): mice pretreated with 0.5 and 1.0 mg/kg ALP showed an increased preference for the subthreshold dose of morphine (MOR, 2.5 mg/kg) when compared to VEH-pretreated controls. Conversely, mice pretreated with 1.0 mg/kg ALP showed aversion-like behavior to a subthreshold dose of MOR (5.0 mg/kg) when compared to the VEH- pretreated mice. (C) Long-term (1 month after the last injection): mice pretreated with 0.5 mg/kg ALP showed an increased preference for the subthreshold dose of MOR (2.5 mg/kg) when compared to VEH-pretreated controls and SAL-conditioned mice. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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