Figure 6 | Scientific Reports

Figure 6

From: Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway

Figure 6

Short-term effects of adolescent repeated ALP exposure on ERK-protein phosphorylation within the NAc 24 h after the last injection. (A) Effects of repeated vehicle (VEH) or alprazolam (ALP; 0.5 mg/kg) exposure in adolescent male mice on protein phosphorylation within the nucleus accumbens (NAc) 24 h after the last injection. Treatment with ALP significantly increased (B) ERK1, (C) ERK2, and (E) AKT phosphorylated forms when compared to VEH-treated controls (p < 0.05, respectively). There was no change in (D) CREB phosphorylation when compared to VEH-treated controls. *p < 0.05, **p < 0.01 when compared to VEH-treated controls. Data are presented as a ratio of total protein normalized to GAPDH (mean ± SEM). See supplementary materials for full-length blots.

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