Figure 9 | Scientific Reports

Figure 9

From: Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway

Figure 9

Long-term effects of adolescent repeated ALP exposure on ERK-related gene expression within the NAc 1 month after the last injection. (A) Effects of repeated vehicle (VEH) or alprazolam (ALP; 0.5 mg/kg) exposure in adolescent male mice on ERK-related gene expression within the nucleus accumbens (NAc) 1 month after the last injection. ALP exposure significantly decreased (B) ERK1 (p < 0.05); (C) ERK2 (p < 0.05); (D) CREB (p < 0.001); and (E) AKT (p < 0.05) mRNA levels when compared to VEH-treated controls. *p < 0.05, ***p < 0.001 compared to VEH-treated controls. Data are represented as fold change normalized to GAPDH (mean ± SEM).

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