Figure 1

Expression heat map of genes included in the 21-gene prognostic signature. Each column represents one patient in the TARGET neuroblastoma discovery cohort (n = 243), and each row represents a gene included in the model. Patients are arranged from low risk (left) to high risk (right) based on the 21-gene risk score and genes are arranged from highest positive association with the risk (bottom) to highest negative association with the risk (top). The line plot demonstrates the risk score of patients as calculated by the 21-gene prognostic signature, with low values associated with low risk and high values associated with high risk (A). For the heatmap, blue represents low expression and orange represents high expression. Genes above the separation are positively associated with risk, and genes below the separation are negatively associated with risk. Clinical variables including MYCN amplification status, INSS stage and age at diagnosis are shown as annotations for each patient in the sample (B).