Figure 4
Screening of the optimal HRGs used for the final construction of the diagnostic model. (A) Correlation heat map of 19 differentially expressed hypoxia-related genes. The size of the colored squares represents the strength of the correlation; blue represents a positive correlation, and red represents a negative correlation. The darker the color is, the stronger correlation is. (B,C) Screening of the optimal parameter (using lambda.1se as the best lambda) at which the vertical lines were drawn. LASSO coefficient profiles of the 19 differentially expressed hypoxia-related genes. (D) Multivariate logistic regression determined independent candidate diagnostic biomarkers.
