Figure 2
Overview of genomic characteristics of whole-genome sequenced advanced RCC cohort. This figure illustrates different genomic characteristics identified by WGS (N = 91). Track (A) shows the tumor mutational burden (mutations per Mb; yellow for low (0–5), orange for medium (5–10) and red for high (> 10)). Track (B) shows the mean genome-wide ploidy, with white representing diploidy. Tracks (C and D) illustrate the abundance of structural variants and the relative frequency of the types of these variants. Tracks (E and F) show the relative mutational signature contribution (COSMIC signatures v3) and the relative frequency of mutational changes at the base level. Track (G) shows the presence of chromothripsis. Track (H) shows whether patients were treatment naive at the time of biopsy. Tracks (I and J) indicate the first treatment given after biopsy (if any) and the first tumor response according to RECIST v1.1, respectively. On the x-axis, the figure is arranged in descending order by tumor mutational burden per RCC subtype. ccRCC = clear cell renal cell carcinoma. pRCC = papillary renal cell carcinoma. Undefined subtype = renal cell carcinoma, with undefined subtype. chRCC = chromophobe renal cell carcinoma. CDC = collecting duct carcinoma. tRCC = tubulocystic renal cell carcinoma. NA = not available.
