Figure 3
Overview of coding variants and copy-number alterations in driver genes in whole-genome sequenced advanced renal cell carcinoma cohort. Overview of findings resulting from the driver gene analysis (N = 91). The oncoplot in track (A) shows variants (filled center) and copy-number alterations (grid cell background) of driver genes determined by dN/dS and GISTIC2.0. Track (B) also shows an oncoplot, but on selected genes, not passing any statistical threshold. Germline pathogenic mutations are indicated with the capital letter ‘G’ (and red border), utilizing the same color coding as the somatic variants. Consequential fusion genes are indicated in yellow, with a red border. Track (C) shows the tumor mutational burden (mutations per Mb; yellow for low (0–5), orange for medium (5–10) and red for high (> 10)). Tracks (D, E and F) shows whether patients were treatment naive at time of biopsy, if systemic treatment was given after time of biopsy, and the first tumor response after systemic treatment according to RECIST v1.1, respectively. Bold sample names with asterisks indicate MiT family translocation RCC. The figure is arranged in descending order by tumor mutational burden per RCC subtype on the x-axis.
