Figure 2 | Scientific Reports

Figure 2

From: ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo

Figure 2

Anticancer action of ARL-17477 is NOS1-independent. (A) Alignment of NOS1 gene sequences of wild-type and NOS1−/− cell lines derived from U251-MG. (B) Growth curves of wild-type (black) and three NOS1−/− cell lines (red, blue, and green). NOS1−/− cell lines retained the normal growth rates with a doubling time of approximately 1.5 days. (C) Cell viability curves following 3 days of ARL-17477 treatment.

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