Table 1 IC50 values of cell viability after 2 days of ARL-17477 treatment.

From: ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo

Cell lines

Cancer type

RAS mutations

IC50 (μM)

SW48

Colon cancer

None

15.0 ± 7.0

U251-MG

Neuroblastoma

None

13.0 ± 2.5

HCT116

Colon cancer

KRAS G13D

7.4 ± 1.3

A549

Lung cancer

KRAS G12S

6.8 ± 1.3

143B

Osteosarcoma

KRAS G12S

4.4 ± 1.0

MIA PaCa-2

Pancreatic cancer

KRAS G12C

4.3 ± 1.3

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