Figure 4
Impact of multiple tumor xenografts on the circulating plasma proteome. (a) Tumor volume versus time for mice implanted subcutaneously with either MDA-MB-231 or MDA-MB-468 (breast); ES-2 or MDAH-2774 (ovarian) and HCT-116 or HT-29 (colon) tumor cells (median, IQR with error bars representing 1.5 × IQR, n = 8, 12, 8 per cell line for breast, ovarian, and colon, respectively). (b) Venn diagram showing the numbers of statistically significant analytes (fdr corrected p-value ≤ 0.05 and a median Log2 fold-change ≥|1|) across all 8 human tumor xenograft models. (c) Plasma signal versus tumor volume for a set of the 4 common markers of tumor volume across tested cell lines. Circles indicate individual SomaScan assay measurements and lines indicate exponential fitting. The plots for the other 11 biomarkers are shown in Supplementary Fig. S4.
