Table 1 SZR104 promotes microglia polarization toward anti‐inflammatory (M2) phenotype.
Cytomorphological features analyzed in automated image analysis workflow | Change after SZR104 as compared to control | p | Change after SZR104 as compared to LPS challenge | p | Change toward anti-inflammatory phenotype |
|---|---|---|---|---|---|
Area | Up | *** | Up | *** | Yes |
Perimeter | Up | *** | Up | *** | Yes |
Circularity | Down | *** | Down | *** | Yes |
Transformation index | Up | *** | Up | *** | Yes |
Convex hull area | Up | *** | Up | *** | Yes |
Convex hull perimeter | Up | *** | Up | *** | Yes |
Mean radius of the convex hull | Up | *** | Up | *** | Yes |
Maximum span across the convex hull | Up | *** | Up | *** | Yes |
Diameter of the bounding circle | Up | *** | Up | *** | Yes |
The ratio max/min convex hull radii | Down | *** | Down | N.S. | Likely |
Convex hull circularity | Up | N.S. | Up | ** | Yes |
Span ratio of the convex hull | Down | N.S. | Down | N.S. | Likely |
Density | Down | N.S. | Down | *** | Yes |
Roughness | Up | *** | Up | *** | Yes |
Fractal dimension | Up | *** | Up | *** | Yes |
Lacunarity | Up | N.S. | Up | *** | Yes |
