Table 3 Univariable and multivariable analysis for graft failure in recipients of non-macrosteatotic grafts from donors ≤ 40 years.

From: Abrogation of greater graft failure risk of female-to-male liver transplantation with donors older than 40 years or graft macrosteatosis greater than 5%

Variables

Univariable analysis

Multivariable analysis

Hazard ratio

p

Hazard ratio

p

Graft factors

 Female-to-male donation

2.22 (1.40–3.53)

0.001

1.88 (1.16–3.04)

0.011

 Donor age (years)

1.01 (0.97–1.04)

0.709

  

 ABO blood type incompatible donor

0.68 (0.33–1.41)

0.301

  

 Graft ischemia time (min)*

1.00 (1.00–1.01)

0.326

  

 Graft-to-recipient weight ratio < 0.8%**

0.73 (0.35–1.52)

0.405

  

 Laparoscopic procurement

0.71 (0.26–1.94)

0.497

  

 Hepatic inflow occlusion***

  1–2 rounds (vs. 0 round)

0.50 (0.26–0.99)

0.046

  

  ≥ 3 rounds (vs. 0 round)

1.08 (0.62–1.87)

0.785

  

Recipient factors

 Age (years)

1.01 (0.98–1.04)

0.467

  

 Body mass index (kg/m2)

0.95 (0.89–1.01)

0.096

0.94 (0.88–0.99)

0.043

 Hypertension

0.77 (0.33–1.76)

0.532

  

 Diabetes

1.28 (0.81–2.02)

0.295

  

 Hepatitis B virus prophylaxis era

  2008–2011 (vs. monoprophylaxis era)

0.74 (0.37–1.50)

0.406

  

  2011–2014 (vs. monoprophylaxis era)

0.84 (0.31–1.31)

0.225

  

 Non-viral etiology

0.86 (0.48–1.56)

0.626

  

 Hepatocellular carcinoma

  Within the Milan criteria (vs. none)

1.32 (0.76–2.29)

0.325

1.57 (0.85–2.91)

0.150

  Beyond the Milan criteria (vs. none)

2.62 (1.52–4.53)

0.001

2.81 (1.54–5.13)

0.001

 MELD score

1.01 (0.99–1.03)

0.438

  

 Neutrophil-to-lymphocyte ratio

1.02 (1.00–1.04)

0.040

  

 Albumin (g/dL)

0.96 (0.67–1.37)

0.801

  

 Platelet count (× 109/L)

1.00 (1.00–1.01)

0.061

  

 Refractory ascites

0.65 (0.36–1.15)

0.138

0.46 (0.24–0.87)

0.017

 Hepatic encephalopathy

  Grade I–II (vs. none)

0.69 (0.35–1.40)

0.306

  

  Grade III–IV (vs. none)

1.38 (0.50–3.80)

0.530

  

 Preoperative continuous renal replacement

2.49 (1.00–6.19)

0.049

5.12 (1.90–13.78)

0.001

 Operative time (min)

1.00 (1.00–1.00)

0.024

  

 Perioperative transfusion****

  Packed red blood cells (units)

1.06 (1.04–1.07)

 < 0.001

1.07 (1.05–1.08)

 < 0.001

  Apheresis platelets (units)*****

1.02 (1.01–1.02)

 < 0.001

  

  Fresh frozen plasma (units)

1.01 (1.00–1.01)

0.048

  

  Cryoprecipitate (units)

1.04 (1.01–1.07)

0.012

  
  1. *Cold ischemia time plus warm ischemia time **There were no recipients with graft-to-recipient weight ratio < 0.6% ***During each round of IHIO, the hepatic artery and the portal vein were clamped for 15 minutes and unclamped for 5 minutes, in general ****During surgery and within 2 weeks after surgery *****One unit of apheresis platelets was considered to be equivalent to 6 units of whole-blood platelets.
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