Table 1 Basic information of the SNAF cohort and characteristics.
Case | Age (yo) | Flap neoplasm type | Primary site | Flap | Adjuvant | Interval | Biopsy time | Flap cancer site | Macroscopic feature | IHC | Sequence | Therapy | Prognosis | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Therapy | (Months) | p53 | p16 | TP53 | ||||||||||
1 | 64 | Cancer | FOM | VFG | None | 118 | 1 | Center | Protruding | ++ | – | * | Local resection | 10 years RFS |
2 | 65 | Cancer | Tongue | RFA | None | 312 | 3 | Center | Papillary | + /− | + | NAD | Total flap resection | 1 year DOD |
3 | 71 | Cancer | Tongue | ALT | RT | 84 | 4 | Center | Papillary | + /− | + | NAD | Local resection | 5 years RFS |
4 | 69 | Cancer | Tongue | ALT | None | 180 | 3 | Center | Protruding | +/− | – | NAD | Total flap resection | 10 years RFS |
5 | 54 | Cancer | Tongue | ALT | None | 36 | 1 | Center | Protruding | – | + | NAD | Follow-up | 1 year DOO |
6 | 86 | Cancer | Lower gum | RAMC | RT | 43 | 1 | Peripheral | Protruding | +/− | + | NAD | Local resection | 5 years RFS |
7 | 70 | Cancer | Upper gum | RAMC | CRT | 24 | 1 | Center | Papillary | ++ | – | missense_ c.734G > T | Local resection | 10 years RFS |
8 | 68 | Precancerous | Tongue | ALT | None | 144 | 2 | Center | Protruding | +/− | + | NAD | Follow-up | 11 years RFS |
9 | 74 | Precancerous | Oropharynx | ALT | None | 156 | 7 | Center | Papillary | ++ | – | missense c.526 T > G | Follow-up | 2 years RFS |
10 | 84 | Precancerous | Hypopharynx | RFA | None | 92 | 5 | Center | Papillary | – | – | stop gained_ c.438G > A | Follow-up | 5 years RFS |
11 | 69 | Precancerous | Oropharynx | ALT | None | 68 | 2 | Center | Papillary | +/− | + | NAD | Follow-up | 6 years RFS |
12 | 68 | Precancerous | Oropharynx | ALT | RT | 46 | 1 | Center | Protruding | + /− | + | NAD | Follow-up | 3 years RFS |
13 | 68 | Precancerous | FOM | NA | None | 168 | 3 | Center | Protruding | +/− | – | NAD | Local resection | 8 years RFS |
14 | 79 | Precancerous | Tongue | RFA | None | 108 | 3 | Center | Protruding | + | + | missense c.480_481delGGinsAA | Follow-up | 2 years RFS |
15 | 78 | Precancerous | Tongue | NA | None | 312 | 1 | Peripheral | Papillary | + | + | missense c.28G > A | Follow-up | 6 years DOO |
16 | 50 | Precancerous | Tongue | ALT | None | 2 | 1 | Peripheral | Protruding | +/− | + | NAD | Follow-up | 9 years RFS |
17 | 56 | Precancerous | FOM | ALT | None | 17 | 2 | Peripheral | Protruding | +/− | – | NAD | Follow-up | 6 years RFS |
18 | 82 | Precancerous | Buccal | Local | None | 83 | 3 | Center | Papillary | +/− | + | NAD | Follow-up | 7 years RFS |
19 | 84 | Precancerous | Buccal | Local | None | 95 | 2 | Center | Papillary | +/− | + | NAD | Follow-up | 1 year RFS |
20 | 70 | Precancerous | Tongue | RAMC | None | 72 | 2 | Center | Protruding | +/− | – | NAD | Follow-up | 2 years RFS |
21 | 80 | Precancerous | Buccal | ALT | None | 150 | 3 | Center | Protruding | +/− | – | NAD | Local resection | 1 year RFS |
