Table 2 Significantly altered metabolites with corresponding AUC scores, Younden index, P-value and VIP-score.

	Metabolite	Metabolomic panel	AUC score	Younden index	P-value	VIP score
1	ADMA	Urea cycle	0.80	0.51641	< 0.00001	2.27
2	Asp	Amino acids	0.76	0.58881	< 0.00001	1.84
3	C6-DC	Acylcarnitines	0.76	0.54105	< 0.00001	1.67
4	Tryptamine	Tryptophan metabolism	0.76	0.54709	< 0.00001	1.85
5	SDMA	Urea cycle	0.75	0.46616	< 0.00001	1.88
6	Indole-3-carboxaldehyde	Tryptophan metabolism	0.74	0.64726	< 0.00001	1.71
7	Orn	Amino acids	0.73	0.61618	< 0.00001	1.63
8	Phe	Amino acids	0.70	0.5775	< 0.00001	1.48
10	C16-1	Acylcarnitines	0.69	0.54058	< 0.00001	1.34
11	Cit	Amino acids	0.69	0.58911	< 0.00001	1.47
12	Indole-3-propionic acid	Tryptophan metabolism	0.69	0.615	< 0.00001	1.05
13	C5-OH	Acylcarnitines	0.68	0.54112	< 0.00001	1.32
15	C0	Acylcarnitines	0.68	0.59459	< 0.00001	1.34
16	Leu	Amino acids	0.68	0.50.641	< 0.0001	1.24
17	C16-1-OH	Acylcarnitines	0.67	0.54207	< 0.0001	1.17
18	Ile	Amino acids	0.67	0.53259	< 0.0001	1.14
19	C16	Acylcarnitines	0.66	0.53065	< 0.0001	1.16
20	C18-OH	Acylcarnitines	0.66	0.54106	< 0.0001	1.20
21	Quinolinic acid	Tryptophan metabolism	0.66	0.56592	< 0.0001	1.07
22	Choline	Urea cycle	0.66	0.50.109	< 0.001	1.16
23	Lysine	Amino acids	0.65	0.52766	< 0.001	1.20
24	Proline	Amino acids	0.65	0.49426	< 0.001	1.19

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