Figure 10 | Scientific Reports

Figure 10

From: Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity

Figure 10The alternative text for this image may have been generated using AI.

Representative traces of first spike latency and rebound action potentials after injection of negative currents (− 0.5 to − 0.1 nA with 0.1 nA increment, holding voltage =  −  60 mV) plotted as a function of K channels following a hyperpolarizing conditioning pulse (− 100 to – 500 pA). Treatment with the small peptides (kunitz4-a, kunitz4-b, and kunitz4-c) is associated with a significant reduction in the rate of rebound action potentials after the application of hyperpolarizing current pulses.

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