Figure 11 | Scientific Reports

Figure 11

From: Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity

Figure 11The alternative text for this image may have been generated using AI.

Effects of the small peptides on Kv currents from cerebellum Purkinje neurons. Representative experiments showing that the small peptides (200 nM) block voltage dependent K+ currents elicited by a pulse of − 60 to 30 mV during 100 ms (holding potential Vh = − 60 mV). Effects of the small peptides on K+ currents are activated by increasing voltage pulses. The K+ currents were recorded following stepwise increments of 10 mV of the membrane voltage between − 60 and 30 mV. (a) Recordings showing the response of one cell in the control group to elicited pulses, and (b) effects of kunitz4-b (200 nM). (c) The four traces of four groups are superimposed on an expanded voltage and time scale.

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