Figure 5
From: Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)
Dose-dependent effects of (9R)-HHC and (9S)-HHC administration (10 mg/kg, i.p.) on the tetrad behavioural tests in mice in comparison to vehicle. Time schedule of the tetrad tests in min from (9R)-HHC, (9S)-HHC or vehicle administration (a). Locomotion decrease induced by (9R)-HHC administration in the open field test (b, f). Decrease of body temperature after (9R)-HHC administration (e); the values are expressed as the difference between the basal temperature (i.e., taken before (9R)-HHC or vehicle administration) and the temperature measured after (9R)-HHC or vehicle administration. Increase in the latency for moving from the catalepsy bar after (9R)-HHC administration (c). Increase in the latency after the first sign of pain shown by the mouse in the hot plate test following (9R)-HHC administration (d). Data are represented as the mean ± SEM of 4 mice per group. * indicates significant differences compared to vehicle injection, *p < 0.05 Tukey’s test.
