Table 1 Immunohistochemistry in patients of BP and MMP.

From: Utility of C3d and C4d immunohistochemical staining in formalin-fixed skin or mucosal biopsy specimens in diagnosis of bullous pemphigoid and mucous membrane pemphigoid

IHC

BP [n (%)]

MMP [n (%)]

P value

Blister+

 C3d

n = 71*

n = 17*

 

  Positive

42 (59.2%)

7 (41.2%)

0.18a

  Negative

29 (40.8%)

10 (58. 8%)

 C4d

n = 71

n = 17

 

  Positive

19 (26.8%)

3 (17.6%)

0.44a

  Negative

52 (73.2%)

14 (82.4%)

Blister−

 C3d

n = 70#

n = 17

 

  Positive

32 (45.7%)

3 (27.7%)

0.043a

  Negative

38 (54.3%)

14 (82.3%)

 C4d

n = 70

n = 17

 

  Positive

11 (15.7%)

0 (0%)

0.113b

  Negative

59 (84.3%)

17 (100%)

  1. Significance values are in bold.
  2. aChi square test.
  3. bFischer’s exact test.
  4. *3 biopsies in BP group and 1 in MMP group could not be interpreted due to inadequate tissue.
  5. #4 biopsies in BP group could not be interpreted due to inadequate tissue. One biopsy which was deemed adequate in Blister+ analysis was considered inadequate in Blister− analysis due to lack of surrounding non-separated skin.
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