Figure 1

Overview of study design and usage of whole head TD-fNIRS neuroimaging in a clinical environment. (a) Study Structure. Screening and dosing visits were conducted at the clinical site. The follow up interview was conducted by phone. (b) Pilot participant wearing the Kernel Flow1 TD-fNIRS system. The TD-fNIRS operator is located to the right outside the image, out of the view of the participant. (c) The Kernel Flow1 TD-fNIRS headset viewed from the outside (top) and inside (bottom). The headset consists of bilateral frontal, temporal, visual, and sensorimotor plates and a total of 52 modules (each with a dual-wavelength source and six detectors). (d) Shown are the parallel streams of data that were captured with the Flow1 system in this experiment. (e) Ketamine dose administered to participants. Each dot represents a participant.