Table 2 Results of cytotoxic activity screened against HepG2 cell line as IC50 in μM.
Compound No. | R1 | R2 | IC50 (μM)* |
|---|---|---|---|
10a | Cl | H | 4.60 ± 0.28 |
10b | Cl | 4-CH3 | 50.83 ± 3.16 |
10c | Cl | 3-CH3 | 4.14 ± 0.25 |
10d | Cl | 2-CH3 | 1.07 ± 0.06 |
10e | Cl | 4-F | 0.88 ± 0.05 |
10f | Cl | 3-CF3 | 62.02 ± 3.87 |
10g | Cl | 4-CN | 43.15 ± 2.59 |
10h | Cl | 4,5-thiazolyl | 14.94 ± 0.52 |
10i | Cl | 4-isopropyl | 1.60 ± 0.17 |
10j | F | H | 41.91 ± 2.52 |
10k | F | 4-CH3 | 34.21 ± 2.06 |
10l | F | 3-CH3 | 14.18 ± 0.82 |
10m | F | 2-CH3 | 13.01 ± 0.75 |
10n | F | 4-F | 2.88 ± 0.14 |
10o | F | 3-CF3 | 2.76 ± 0.1 |
10p | F | 4-isopropyl | 8.14 ± 0.47 |
Sorafenib | – | – | 8.38 ± 0.5 |
