Table 3 Univariate and multivariate analysis for overall survival and PFS.

From: A promising predictive biomarker combined EBV NDA with PNI for nasopharyngeal carcinoma in nonendemic area of China

 

OS

PFS

Univariate

Multivariate

Univariate

Multivariate

Variables

N (%)

X2

P

HR (95% CI)

P

X2

P

HR (95% CI)

P

Age

 

24.67

 < 0.001

2.427 (1.428–4.115)

0.001

16.113

0.006

1.873(1.195,2.933)

0.001

 ≤ 50.5y

236 (47.8)

        

 > 50.5y

257 (52.2)

        

Gender

 

0.722

0.396

  

2.752

0.97

  

 Female

147 (29.8)

        

 Male

346 (70.2)

        

T stage

 

10.52

0.001

2.298 (1.290, 4.098)

0.005

7.741

0.005

1.815(1.105,2.985)

0.019

 T1–2

155(31.44)

        

 T3–4

338(68.56)

        

N stage

   

1.197 (0.740–1.934)

0.463

    

 N0-2

377(76.47)

9.661

0.002

  

8.989

0.003

  

 N3

116(23.53)

        

M stage

 

51.0

 < 0.001

1.964 (1.267, 3.040)

 < 0.001

50.297

 < 0.001

1.964 (1.267, 3.040)

 < 0.001

 M0

456(92.49)

        

 M1

37(7.51)

        

Pathology type

 

0.165

0.684

  

0.003

0.955

  

 Keratinizing

15(3.04)

        

 Non-keratinizing

478(96.96)

        

Alcohol

 

9.277

0.002

1.616 (0.918, 2.841)

0.960

5.808

0.016

1.333(0.802,2.217)

0.268

 Yes

151()

        

 No

342()

        

Smoking

 

8.286

0.004

1.383 (0.791, 2.415)

0.255

6.235

0.013

1.395(0.854,2.294)

0.189

 Yes

282()

        

 No

211()

        

EBV-DNA

 

32.12

 < 0.001

2.584 (1.645, 4.049)

 < 0.001

22.074

 < 0.001

1.97(1.302,2.976)

0.001

 ≤ 262.7

317(64.3)

        

 > 262.7

176(35.7)

        

 PNI

 

19.04

 < 0.001

2.083(1.153,3.773)

0.015

11.02

0.001

1.284 (0.766, 2.155)

0.343

 > 52.62

189(38.3)

        

 ≤ 52.62

304(61.7)

        

NLR

 

8.13

0.004

1.408 (0.887,2.237)

0.147

5.120

0.024

1.30 (0.854, 1.981)

0.221

 ≤ 2.61

253(51.3%)

        

 > 2.61

240(48.7%)

        

 =HGB(g/L)

 

7.768

0.005

0.706(0.445,1.200)

0.139

3.877

0.049

1.255 (0.821, 1.917)

0.294

 > 138.5

216(43.8%)

        

 ≤ 138.5

277(56.2%)

        

WBC

 

0.605

0.437

  

0.121

0.728

  

 ≤ 6.05

237(48.1%)

        

 > 6.05

256(51.9%)

        
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