Table 5 Parameter values of the model \({\mathrm{PKPD}}_{\mathrm{lin},\mathrm{mm}}^{6\mathrm{MP}}\) estimated with the whole and the cross-validation data set, relative standard error (RSE) of fixed effect parameters and residual unexplained variability in brackets.
| Â | \({PKPD}_{lin,mm}^{6MP}\) | \({PKPD}_{lin,mm}^{6MP}\), cross-validation | ||
|---|---|---|---|---|
Fixed effect parameters with RSE in % | CV with 95% CI, η-Shrinkage in % and p-values | Fixed effect parameters with RSE in % | CV with 95% CI, η-Shrinkage in % and p-values | |
\({K}_{in}^{MTX}\)[1/day] | 0.032 (1) | 34 [29, 38], 29, 0.75 | 0.029 (2) | 35 [30, 40], 34, 0.86 |
\({K}_{eff}^{MTX}\)[1/day] | 0.019 (1) | 31 [26, 35], 30, 0.77 | 0.018 (1) | 26 [20, 31], 45, 0.72 |
\({V}_{mm}^{6MP}\)[µmol/L/day] | 0.21 (4) | 56 [46, 65], 27, 0.97 | 0.13 (4) | 42 [34, 50], 35, 0.98 |
\({K}_{mm}^{6MP}\)[µmol/L] | 0.14 (0.1) | - | 0.046 (7) | - |
\({K}_{eff}^{6MP}\)[1/day] | 0.050 (2) | 54 [45, 63], 29, 0.97 | 0.044 (2) | 44 [37, 51], 33, 0.91 |
\(base\)[G/L] | 2.17 (3) | 27 [24, 31], 22, 0.68 | 2.08 (4) | 29 [25, 32], 27, 0.78 |
\({k}_{tr}\)[1/day] | 0.15 (2) | 72 [60, 82], 35, 0.57 | 0.17 (3) | 72 [60, 84], 46, 0.65 |
\({slope}^{6MP}\)[L/µmol] | 0.16 (4) | 81 [65, 97], 40, 0.68 | 0.15 (6) | 93 [68, 117], 45, 0.96 |
Îł | 0.79 (5) | 11[8, 12], 49, 0.89 | 0.82 (10) | 15 [11, 18], 58, 0.54 |
\(inieff\) | 0.87 (22) | 54 [48, 59], 20, 0.63 | 0.88 (29) | 48 [42, 53], 27, 0.69 |
Residual unexplained variability | ||||
Additive, MTX | 0.000018 (7) | 0.000022 (8) | ||
Proportional, MTX | 0.024 (8) | 0.0074 (25) | ||
Additive, 6MP | 0.024 (9) | 0.020 (10) | ||
Proportional, 6MP | 0.061 (5) | 0.051 (6) | ||
Proportional, ANC | 0.25 (2) | 0.22 (3) | ||
