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Figure 2

From: Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets

Figure 2

Offspring social, and grooming behavior are not altered by VPA following both n-3 PUFA diets. (a) Phase II from the 3-CT in both males (left) and females (right females). n = 27 (SAL/n-3 bal male), 25 (VPA/n-3 bal male), 35 (SAL/n-3 supp male), 25 (VPA/n-3 supp male), 39 (SAL/n-3 bal female), 27 (VPA/n-3 bal female), 27 (SAL/n-3 supp female) and 26 (VPA/n-3 supp female) mice. Data are expressed as mean ± SEM and were analyzed through a three-way ANOVA followed by Tukey post-hoc multiple analysis. *p < 0.05, **p < 0.01, ***p < 0.001. SC social chamber, NSC non-social chamber. (b) Number of grooming episodes and cumulative grooming duration in both males (left) and females (right). (c) Number of rearing episodes and cumulative rearing duration in both males (left) and females (right). n = 28 (SAL/n-3 bal male), 27 (VPA/n-3 bal male), 35 (SAL/n-3 supp male), 24 (VPA/n-3 supp male), 37 (SAL/n-3 bal female), 27 (VPA/n-3 bal female), 26 (SAL/n-3 supp female) and 26 (VPA/n-3 supp female) mice. Data are expressed as mean ± SEM and were analyzed through a three-way ANOVA for 3-CT or two-way ANOVA for grooming and rearing behavior, followed by Tukey post-hoc multiple analysis. *p < 0.05, **p < 0.01, ***p < 0.001.

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