Figure 6 | Scientific Reports

Figure 6

From: Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord

Figure 6

Responses of iCRs to opioids tested in RorbCreERT2;Ai9 mice. (a) Examples of responses to the μ-opioid agonist DAMGO, the δ-opioid agonist deltorphin II and the κ-opioid agonist U-69593. The cell tested with DAMGO showed an outward current (top trace), while those tested with Deltorphin II (middle trace) and U-69593 (bottom trace) did not respond. (b) The proportions of cells that were sensitive or insensitive to each agonist. (c) The amplitudes of responses to the agonists for each cell tested, with mean and SD of the cells sensitive to each agonist. The dashed line represents a value of 5 pA, which was taken as the threshold for defining a responsive cell.

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