Figure 5 | Scientific Reports

Figure 5

From: Insights into peculiar fungal LPMO family members holding a short C-terminal sequence reminiscent of phosphate binding motifs

Figure 5

Structural comparison of the “9res” motif with canonical phosphate binding motifs. (A) ATP-dependent enzyme (PDB id 2OLR)47. In the canonical sequence “GXXXXGK(S/T)”, the lysine residue is crucial for the coordination of the nucleotide β- and γ-phosphates while the serine/threonine residue ensure the coordination a Mg2+-ATP complex required for its hydrolysis41,48,49. ATP is colored in blue and the Mg2+ cation is colored in green. (B) PcoAA9-X282-9res structure prediction (AlphaFold2) and zoom-in view of the 9res motif, colored in orange. (C) Zoom-in of the NADPH binding site of a canonical NADPH oxidase crystal structure (PDB id 5FF9)50. Key amino acids from the P-loop involved in phosphate binding are colored in orange. NADPH is colored in red.

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