Table 1 Synthesis of dicytidine H-phosphonamidate 2-mers (CPHC).

From: Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

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Entry

Condensing reagent

NMR yield (%)a

1

PivCl

0

2

BOPCl

98

3

PyBOP

67

4

BOMP

98

5

PyNTP

98

6

MNTP

90

  1. aDetermined by 31P NMR.
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