Table 1 Sensitivity and specificity of MB-AuNP-I-PCR, I-PCR and Magneto-ELISA at 95% CI based on LAM+MPT-64 detection within urine EVs of GUTB patients/non-TB controls, against CRS as the reference standard.

From: Diagnosis of genitourinary tuberculosis: detection of mycobacterial lipoarabinomannan and MPT-64 biomarkers within urine extracellular vesicles by nano-based immuno-PCR assay

Categories of GUTB

MB-AuNP-I-PCR

I-PCR

Magneto-ELISA

(+)

% Sensitivity

% Specificity

(+)

% Sensitivity

% Specificity

(+)

% Sensitivity

% Specificity

Confirmed (n = 7)

7

100 (59–100)

 

6

85.7 (42.1–99.6)

 

5

71.4 (29–96.3)

 

Clinically suspected (n = 40)

34

†85 (70.2–94.3)

 

26

†65 (48.3–79.4)

 

24

†60 (43.3–75.1)

 

Total GUTB (n = 47)

41

*87.2 (74.3–95.2)

 

32

*68.1 (52.9–80.9)

 

29

*61.7 (46.4–75.5)

 

Non-TB controls (n = 35)

1

 

97.1 (85.1–99.9)

3

 

91.4 (76.9–98.2)

3

 

91.4 (76.9–98.2)

  1. Significant differences (p < 0.05–0.01) were noted between the sensitivities of †clinically suspected and *total GUTB cases by MB-AuNP-I-PCR, compared with I-PCR and Magneto-ELISA, using exact symmetry test.
  2. n, number of samples; (+), positive cases; GUTB, genitourinary tuberculosis.
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