Figure 3
Effect of trypsin treatment on SARS-CoV-2 infection using clinical specimens. Comparison of clinical specimens of the (A) delta (n = 56) and (B) omicron (n = 44) variants by Ct value at PCR testing. The load of viral genome after viral amplification with trypsin treatment is expressed as the infection enhancement ratio, where the amount of viral genome after viral amplification without trypsin treatment is set as 1. Filled circle; Relative viral genome quantity of trypsin (400 μg/mL)-treated specimens, open triangle; Relative viral genome quantity of specimens not treated with trypsin. (C) Boxplot analysis combining the results of (A) and (B). Regarding the ratio, the same as (A) and (B) without trypsin treatment is set as 1. Significance was determined by the Mann–Whitney U-test: ***P < 0.001.
